The Region of East Macedonia – Thrace makes up the north-eastern part of Greece. To the east it borders with Turkey, to north with Bulgaria and to the south with the Region of Central Macedonia, and in particularly with the Prefecture of Serres. To the South – West it is wet by the Aegean Sea and to the south-east by the Thracian Sea. The Region consists of five prefectures: Kavala, Drama, Xanthi, Rodopi and Evros.

The Region’s area is 14.157 km2 corresponding to 10,7% of Greece’s total area. Three big rivers, the rivers Nestos, Strymonas and Evros, pass through the region. Nestos is the natural border between Eastern Macedonia and Thrace. Many lakes are also found in the Region and meet with rivers.